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In Vitro Pharmacology
Gastrointestinal
Model | In vitro model for digestive stimulants |
Test system | Estimation of digestive enzyme activities using biochemical assays:
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Method | Evaluation of test compound’s effect on the activities of digestive enzymes of gastrointestinal tract |
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Model |
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Test system |
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Method | Preparation of pancreatic and intestinal homogenates from wistar rat Treatment with test item Pancreatic amylase, Lipase, Trypsin & Chymotrypsin Intestinal Sucrase, Lactase & Maltase |
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Anti-ulcer potential |
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Method | Anti-oxidant -DPPH/ABTS assay ?Acid neutralizing capacity -Titrimetric assays with NaOH Cytoprotection in AGS cell line -Treatment of AGS cells with test item (5 concentrations) -Exposure of cells to acidic medium (pH-3)/Indomethacin/ethanol -Effect of test item on survival of cell |
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