LIVER HEALTH

Study Title	Reference Drug	End point Parameters
Hepatoprotective activity using CCl4 induced rat / Mice model	Silymarin	SGOT, SGPT, Bilirubin, GGT, body weight, feed consumption & liver histology
Hepatoprotective activity using Ethanol induced rat / Mice model	Silymarin	SGOT, SGPT, Bilirubin, GGT, body weight, feed consumption & liver histology
Hepatoprotective activity using Paracetamol induced rat / Mice model	Silymarin	SGOT, SGPT, Bilirubin, GGT, body weight, feed consumption & liver histology
Con-A induced Liver inflammation model in mice	Silymarin	SGOT, SGPT, Bilirubin, GGT, Serum Cytokines (TNF alpha & IFN gamma) liver histology

FERTILITY

Study Title	Reference Drug	End point Parameters
Aphrodisiac activity using mating behaviour test Male & Female Rats	Ashwagandha	No. of mounting, Intromission time & latency , Testosterone level , body weight , Etc…
Erectile dysfunction: Isolated tissue preparation – Corpora cavernosa contraction test	Sildenafil Citrate	% Contarction & % Relaxation of CC tissue

ADVERSE EFFECT

Study Title	Reference Drug	End point Parameters
Ex-vivo haemolysis assay using rabbit blood	SDS	% hemolysis

NON-GLP SAFETY

Study Title	Reference Drug	End point Parameters
Determination MTD to select safe dose for efficacy studies using Mice	NA	% Body weight change, Mortality, Hematology & biochemistry

ANEMIA

Study Title	Reference Drug	End point Parameters
Phenyl hydrazine- induced anemia model using Rats	Fe sulphaste	Hb Level , complete heamatology & biochemistry

KIDNEY HEALTH

Study Title	Reference Drug	End point Parameters
Nephroprotective Activity using Gentamycin induced rat model	—	Kidney function test, Histology of kidney, urinanalysis

CARDIAC HEALTH

Study Title	Reference Drug	End point Parameters
L-NAME and High Fat Diet -induced cardiac abnormalities using rats	Atorvastatin + Captopril	Blood pressure, lipid profile, serum cytokines, histology of vital organs

LUNG HEALTH

Study Title	Reference Drug	End point Parameters
Bleomycin induced lung fibrosis model in C57BL6 Mice	Pirfenidone	BALF – cytokine (IL1beta & TNF alpha) Lung biomarker (TGF beta, IL1beta) & Histology of Lung
Pollutant (PM2.5/Ovalbumin/LPS) induced lung inflammation model in BALB/c Mice	—	Cytokine (TNF alpha, IL6, IgE, etc..) level in BALF & Lung, and histology of Lung

IMMUNOMODULATION

Study Title	Reference Drug	End point Parameters
Cyclophosphmaide/pyrogallol induced immunosuppression model in rats	Levamizole	Sheep RBC -Titer Value, IFN gamma in serum, Heamogram
Cyclophaophamide-Induced Thrombocytopenia in Sprague Dawley Rats	Papaya extract	Heamogram Platelet count Complete blood count, Hb

ENERGY

Study Title	Reference Drug	End point Parameters
Anti-fatigue actvity using weight loaded swim endurance model in rats	—	Swimmimg time, Lactate level in blood,

OPTHOLMOLOGY

Study Title	Reference Drug	End point Parameters
Sodium selenite -induced cataract model in young rats	Triphala drops	Cataract grade, Opacity score of isolated lens, Slit lamp examination