dabur

Est.1979

Providing Integrated Research Solutions in Preclinical Biology

Bioanalytical

  • Fit for purpose methods (small and larger molecules)
  • bioanalytical method validation (small and larger molecules)
  • Quantitative determination of biomarker in plasma and tissues
  • Chemical derivatization techniques to improve chromatographic behavior and ionization efficiency
  • Extraction technique : protein precipitation, Liquid liquid extraction, Solid Phase Extraction
  • Impurity profiling
  • Metabolite identification
Herb-Drug Interaction Background Herb-Drug interaction is a situation in which constituent/s of herbal extract or product affects the activity of a drug when administered together. Millions of people today use herbs either as food or in the form of medicine along with prescription and nonprescription medications. Although considered natural and safe, many of these herbs can interact with other medications, causing either potentially dangerous side effects and/or reduced benefits from the medication. Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Due to the limitation of availability of experimental data in this area, there is a huge need to perform herb-drug interaction studies with herbal products. Assay offered for Herb-Drug Interaction In-Vitro methods
Model In-vitro model for drug-drug or herb-drug interaction 
Test System Human Liver Microsomes or recombinant enzymes
Method Co-incubation of herb-drug or drug-drug with CYP enzymes
Quantitation method   HPLC-UV or LC/MS/MS or Fluorescence reader 
End Point Metabolite formation
Deliverables Percent inhibition, IC50 determination
Model In-vitro model for drug-drug or herb-drug interaction 
Test System Liver cell lines
Method Co-incubation of herb-drug or drug-drug with CYP enzymes
Quantitation method   HPLC-UV or LC/MS/MS or Fluorescence  reader 
End Point Metabolite formation
Deliverables Percent inhibition, IC50 determination
In-Vivo methods
Model Pharmacokinetics 
Test System Rodents
Method Co-administration of drug with herbal product
Quantitation method   HPLC-UV or LC/MS/MS 
End Point PK parameter evaluation of drug
Deliverables Impact of herb on PK profile of drug
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