- Multiple strains of rat – Healthy & Disease Model
- Multiple Strains of mouse – Healthy & Disease Model
- Various routes of administration
- Dose linearity Studies
- Single Dose, Multiple dose, Cassette Dosing
- Route of Excretion (Urine & Faeces)
Tissue Distribution/Biodistribution in rodents
- Exposure kinetics in skin, plasma & various organs like liver, heart, spleen etc.
- Exposure to brain, CSF collection
Dermal PK in rodents
- Healthy & Disease Mode
Bioavailability in rodents
- Absolute bioavailability against IV administration
- Comparative bioavailability
Statistical analysis of PK data using Phoenix Winnonlin
- Détermination of PK parameter Cmax, Tmax, AUC, MRT, CL etc.