dabur

Est.1979

Providing Integrated Research Solutions in Preclinical Biology

Liver health

Study Title Reference Drug End point Parameters
Hepatoprotective activity using CCl4 induced rat / Mice model Silymarin SGOT, SGPT, Bilirubin, GGT, body weight, feed consumption & liver histology
Hepatoprotective activity using Ethanol induced rat / Mice model Silymarin SGOT, SGPT, Bilirubin, GGT, body weight, feed consumption & liver histology
Hepatoprotective activity using Paracetamol induced rat / Mice model Silymarin SGOT, SGPT, Bilirubin, GGT, body weight, feed consumption & liver histology
Con-A induced Liver inflammation model in mice Silymarin SGOT, SGPT, Bilirubin, GGT, Serum Cytokines (TNF alpha & IFN gamma) liver histology

Fertility

Study Title Reference Drug End point Parameters
Aphrodisiac activity using mating behaviour test Male & Female Rats Ashwagandha No. of mounting, Intromission time & latency , Testosterone level , body weight , Etc…
Erectile dysfunction: Isolated tissue preparation – Corpora cavernosa contraction test Sildenafil Citrate % Contarction & % Relaxation of CC tissue

Adverse effect

Study Title Reference Drug End point Parameters
Ex-vivo haemolysis assay using rabbit blood SDS % hemolysis

Non-GLP safety

Study Title Reference Drug End point Parameters
Determination MTD to select safe dose for efficacy studies using Mice NA % Body weight change, Mortality, Hematology & biochemistry

Anemia

Study Title Reference Drug End point Parameters
Phenyl hydrazine- induced anemia model using Rats Fe sulphaste Hb Level , complete heamatology & biochemistry

Kidney health

Study Title Reference Drug End point Parameters
Nephroprotective Activity using Gentamycin induced rat model Kidney function test, Histology of kidney, urinanalysis

Cardiac Health

Study Title Reference Drug End point Parameters
L-NAME and High Fat Diet -induced cardiac abnormalities using rats Atorvastatin + Captopril Blood pressure, lipid profile, serum cytokines, histology of vital organs

Lung Health

Study TitleReference DrugEnd point Parameters
Bleomycin induced lung fibrosis model in C57BL6 MicePirfenidoneBALF – cytokine (IL1beta & TNF alpha) Lung biomarker (TGF beta, IL1beta) & Histology of Lung
Pollutant (PM2.5/Ovalbumin/LPS) induced lung inflammation model in BALB/c MiceCytokine (TNF alpha, IL6, IgE, etc..) level in BALF & Lung, and histology of Lung

Immunomodulation

Study Title Reference Drug End point Parameters
Cyclophosphmaide/pyrogallol induced immunosuppression model in rats Levamizole Sheep RBC -Titer Value, IFN gamma in serum, Heamogram
Cyclophaophamide-Induced Thrombocytopenia in Sprague Dawley Rats Papaya extract Heamogram Platelet count Complete blood count, Hb

Energy

Study Title Reference Drug End point Parameters
Anti-fatigue actvity using weight loaded swim endurance model in rats Swimmimg time, Lactate level in blood,

Optholmology

Study Title Reference Drug End point Parameters
Sodium selenite -induced cataract model in young rats Triphala drops Cataract grade, Opacity score of isolated lens, Slit lamp examination
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