dabur

Est.1979

Providing Integrated Research Solutions in Preclinical Biology

Inflammation

Study Title Reference Drug End point Parameters
TNBS induced Inflammatory Bowel Disease (IBD) Model in Mice Sulfasalazine Colitis clinical score, Body weight, Cytokine (IL1beta, TNF alpha) level in colon tissue & serum, Histology
LPS induced Sepsis Model in Mice Dexamethasone Cytokine ( TNF alpha & IL6)levels in serum
LPS induced Lung inflammation model in Mice Dexamethasone Cytokine (TNF alpha & IL6) levels in serum & Lung tissue homogenate
Monosodium Iodoacetate (MIA)-induced Osteoarthritis (OA) in Wistar Rats NSAID Pain sensitivity by Pressure application in knee joint, Collagen at knee joint , knee joint histology etc
DSS induced ulcerative colitis model in mice Sulfasalazine UC score, Body weight, Cytokine level in colon tissue & serum, Histology
Anti-Inflammatory Activity by Carrageenan Induced Paw Edema using Rat / Mice Indomethacin Absolute paw volume, Edema, % activity & PGE2 COX in paw tissue or serum, Pain sensitivity
Anti-Arthritic Potential of Test Item on Rat Adjuvant (CFA) Induced Arthritis Dexamethasone,Methotrexate Arthritis Score, Paw volume, Body weight, Serum Biomarkers (TNF alpha, IL6 , CRP etc..) , Radiography & Histology of Hind paw
Collagen-induced Arthritis in Rats Dexamethasone,Methotrexate Arthritis Score, Paw volume, Body weight, Serum Biomarkers (TNF alpha, IL6 , CRP etc..) , Radiography & Histology of Hind paw
Ceccal Slurry induced SIRS Model in rats Dexamethasone Clinical sign score, Body weight, survival analysis, Cytokine level (TNF alpha, IFN gamma, IL6, IL1beta etc..)is serum and variuos tissues & Histology
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