SARS CoV2 Spike protein induced Lung inflammation model in BALB/c Mice |
Dexamethasone |
Gross pathology of Lung, Cytokine (IL1beta, IL6 etc..) in BALF, Histopathological investigation of Lung |
In-vivo efficacy of test item against intranasal SARS-CoV2 model in hamster |
Remdesivir |
Clinical sign, Body weight change, Lung viral titer, Cytokine gene in spleenocyte, Histopathology of lung |
In-vivo efficacy of test item against intranasal influenza virus model in BALB/c mice |
Oseltamivir |
Clinical score, Body weight change, survival, Viral load in lung & nasal wash, Cytokine level in BALF, Plasma , Histopathology of lung |